NAD+ Infusions in Berlin

What are NAD+ infusions used for?

Mitochondria are often referred to as the 'powerhouses of the cell'. They convert nutrients and oxygen into ATP, thereby providing most of the energy a cell needs. NAD+ is directly involved in this process.

Patients are primarily interested in NAD+ infusions in the following situations:

• Fatigue and exhaustion in everyday life
• Phases of high professional or physical stress
• Desire for support in concentration and performance
• Interest in preventive approaches in longevity medicine

Important for your decision: The basic research on NAD+ is extensive, but the clinical study data on intravenous administration in humans is still limited. An NAD+ infusion is not intended for the treatment of diseases and does not replace medical diagnostics or therapy. For persistent symptoms, the cause should first be medically clarified.

How does NAD+ work?

NAD+ fulfills two fundamental tasks in the body. As an electron carrier, it is involved in the conversion of nutrients into energy. As a substrate, it is consumed by enzymes that control repair and regulatory processes in the cell. These include sirtuins and PARP enzymes, which are involved in DNA repair, among other things. Another enzyme, CD38, breaks down NAD+. In animal models, its activity increases with age, which is considered a possible cause for declining NAD+ levels.

During an infusion, NAD+ enters the bloodstream directly via the vein, bypassing the gastrointestinal tract. How much of it reaches the cells of individual tissues and what effects result from this in humans is currently being researched. Anecdotal reports describe, among other things, more energy and better concentration. However, such effects have not yet been proven by controlled studies.

What is known about NAD+ in old age?

It is often stated that NAD+ levels halve by the age of 40. The data is not that clear-cut. Studies on individual human tissues, such as skin and brain, show lower NAD+ levels with increasing age. In MRI studies of the brain, the decline between young and old adulthood was about 10 to 25 percent. Reliable data is lacking for many other tissues.

Possible causes include higher consumption of NAD+ due to repair and inflammatory processes, as well as lower endogenous production. Whether aging processes in humans can be influenced by raising NAD+ levels is the subject of ongoing research.

What NAD+ therapies are available?

NAD+ can be administered in two ways. Orally, precursors such as Nicotinamide Riboside (NR) or Nicotinamide Mononucleotide (NMN) are usually taken, which the body converts into NAD+. In an infusion, NAD+ itself is administered intravenously.

At Metropolitan Aesthetics, NAD+ therapy is administered as an infusion under medical supervision. We use NAD+ from METROBOOST, which is produced in a pharmacy and supplied as a freeze-dried powder (lyophilisate). In this form, the active ingredient is significantly more stable than in dissolved form. The powder is dissolved and added to a Ringer's solution immediately before treatment.

Before the first infusion, we discuss your initial situation, pre-existing conditions, and medications. Dosages of 62.5 mg and 125 mg are available. The infusion takes at least 1.5 hours for 62.5 mg, and about 2 to 2.5 hours for 125 mg. NAD+ is deliberately administered slowly: if given too quickly, temporary nausea, warmth, tingling, muscle cramps, or a feeling of pressure in the chest may occur. These symptoms usually subside as soon as the infusion is slowed down.

Treatment usually takes place as a series. The manufacturer recommends two infusions per week for two weeks initially, followed by one infusion per week for four weeks. After that, treatment can be continued every two to four weeks as needed. NAD+ infusions are prescription-only.

The science behind NAD+

NAD+ and NADH form a so-called redox pair: two forms of the same molecule that differ by the uptake or release of electrons. During the breakdown of glucose and fatty acids, NAD+ takes up electrons and becomes NADH. In the mitochondria, NADH transfers these electrons to the respiratory chain. The energy released in this process is used by the cell to form ATP (adenosine triphosphate), and NAD+ is ready for the next cycle.

Mitochondria are found in almost all body cells, particularly numerous in tissues with high energy demands such as the heart, brain, and muscles. Without NAD+, the cell cannot convert nutrients into usable energy.

What research currently shows

In animal models, favorable effects on metabolism and aging processes have been observed with higher NAD+ levels. These results cannot be directly transferred to humans. Clinical studies have predominantly been conducted with oral precursors and show that NAD+ levels in the blood can be increased. A clear health benefit has not yet been proven. For intravenous administration, primarily smaller studies and observational data are available. Current review articles from 2025 and 2026 conclude that controlled studies on anti-aging or wellness effects of NAD+ infusions are currently lacking. We will openly inform you about this status during the consultation.

What does an NAD+ infusion cost?

The costs depend on the dosage and number of infusions. Infusions are a self-pay service. We will inform you of the exact amount during the consultation or gladly in advance by email or phone.